Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU001858 |
| Korean Unigene Clone | IRAT-20-C10 | |
| Original Clone | IRAK-26-O11 | |
| Vector | pCMV-SPORT6 | |
| Gene | ADORA2A | |
| Gene Description | adenosine A2a receptor | |
| Clone sequence size | 2518 (bp) | |
| Fullness | F | |
| Mutation | 1503 | |
| Amino acid - mutation | TAT(Y)-> TAC(Y) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 2518 |
| Sequence | GCAGGAGCCGCCCCCAGCCAAGCTGCTTTCAGCACAGCGTGGGCC CCCAGCACCTTGGTGCGGGGTGCGGCCCCTCGGAGGAGGGCTGTC AGGTGAAGCCTCGTGTGAGGGGGTGCCTCAGGAACCCTGAAGCTG GGCTGAGCCATGATGCTGCTGCCAGAACCCCTGCAGAGGGCCTGG TTTCAGGAGACTCAGAGTCCTCTGTGAAAAAGCCCTTGGAGAGCG CCCCAGCAGGGCTGCACTTGGCTCCTGTGAGGAAGGGGCTCAGGG GTCTGGGCCCCTCCGCCTGGGCCGGGCTGGGAGCCAGGCGGGCGG CTGGGCTGCAGCAATGGACCGTGAGCTGGCCCAGCCCGCGTCCGT GCTGAGCCTGCCTGTCGTCTGTGGCCATGCCCATCATGGGCTCCT CGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCCATCC TGGGCAATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACC TGCAGAACGTCACCAACTACTTTGTGGTGTCACTGGCGGCGGCCG ACATCGCAGTGGGTGTGCTCGCCATCCCCTTTGCCATCACCATCA GCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATTGCCT GCTTCGTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGG CCATCGCCATTGACCGCTACATTGCCATCCGCATCCCGCTCCGGT ACAATGGCTTGGTGACCGGCACGAGGGCTAAGGGCATCATTGCCA TCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATGCTAG GTTGGAACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCC AGGGCTGCGGGGAGGGCCAAGTGGCCTGTCTCTTTGAGGATGTGG TCCCCATGAACTACATGGTGTACTTCAACTTCTTTGCCTGTGTGC TGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATCTTCC TGGCGGCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGC CGGGGGAGCGGGCACGGTCCACACTGCAGAAGGAGGTCCATGCTG CCAAGTCACTGGCCATCATTGTGGGGCTCTTTGCCCTCTGCTGGC TGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCCGACT GCAGCCACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCT CCCACACCAATTCGGTTGTGAATCCCTTCATCTACGCCTACCGTA TCCGCGAGTTCCGCCAGACCTTCCGCAAGATCATTCGCAGCCACG TCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGTGCCC GGGTCTTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCC GTCTCAACGGCCACCCGCCAGGAGTGTGGGCCAACGGCAGTGCTC CCCACCCTGAGCGGAGGCCCAATGGCTACGCCCTGGGGCTGGTGA GTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTCCCAG ACGTGGAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGC CCCCTGGCCTAGATGACCCCCTGGCCCAGGATGGAGCAGGAGTGT CCTGATGATTCATGGAGTTTGCCCCTTCCTAAGGGAAGGAGATCT TTATCTTTCTGGTTGGCTTGACCAGTCACGTTGGGAGAAGAGAGA GAGTGCCAGGAGACCCTGAGGGCAGCCGGTTCCTACTTTGGACTG AGAGAAGGGAGCCCCAGGCTGGAGCAGCATGAGGCCCAGCAAGAA GGGCTTGGGTTCTGAGGAAGCAGATGTTTCATGCTGTGAGGCCTT GCACCAGGTGGGGGCCACAGCACCAGCAGCATCTTTGCTGGGCAG GGCCCAGCCCTCCACTGCAGAAGCATCTGGAAGCACCACCTTGTC TCCACAGAGCAGCTTGGGCACAGCAGACTGGCCTGGCCCTGAGAC TGGGGAGTGGCTCCAACAGCCTCCTGCCACCCACACACCACTCTC CCTAGACTCTCCTAGGGTTCAGGAGCTGCTGGGCCCAGAGGTGAC ATTTGACTTTTTTTCCAGGAAAAATGTAAGTGTGAGGAAACCCTT TTTATTTTATTACCTTTCACTCTCTGGCTGCTGGGTCTGCCGTCG GTCCTGCTGCTAACCTGGCACCAGAGCCTCTGCCCGGGGAGCCTC AGGCAGTCCTCTCCTGCTGTCACAGCTGCCATCCACTTCTCAGTC CCAGGGCCATCTCTTGGAGTGACAAAGCTGGGATCAAGGACAGGG AGTTGTAACAGAGCAGTGCCAGAGCATGGGCCCAGGTCCCAGGGG AGAGGTTGGGGCTGGCAGGCCCCTGGCATGTGCTGAGTAGCGCAG AGCTACCCAGTGAGAGGCCTTGTCTAACTGCCTTTCCTTTTAAAG GGAATGTTTTTTTTTGAGATAAAATAAAAACGAGCCACATCGTGT TTTAAGCTTGTCCAAATGAAAAAAAAAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 22 | |||||||||||
| Location | 22q11.23 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_000675 | |||||||||||
| KEGG Genes | 135 | ||||||||||||
| GeneCard | ADORA2A |
| sequence | sequence of CDS | ATGCCCATCATGGGCTCCTCGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCCATCCTGGGCAATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACCTGCAGAACGTCACCAACTACTTTGTGGTGTCACTGGCGGCGGCCGACATCGCAGTGGGTGTGCTCGCCATCCCCTTTGCCATCACCATCAGCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATTGCCTGCTTCGTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGGCCATCGCCATTGACCGCTACATTGCCATCCGCATCCCGCTCCGGTACAATGGCTTGGTGACCGGCACGAGGGCTAAGGGCATCATTGCCATCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATGCTAGGTTGGAACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCCAGGGCTGCGGGGAGGGCCAAGTGGCCTGTCTCTTTGAGGATGTGGTCCCCATGAACTACATGGTGTACTTCAACTTCTTTGCCTGTGTGCTGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATCTTCCTGGCGGCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGCCGGGGGAGCGGGCACGGTCCACACTGCAGAAGGAGGTCCATGCTGCCAAGTCACTGGCCATCATTGTGGGGCTCTTTGCCCTCTGCTGGCTGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCCGACTGCAGCCACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCTCCCACACCAATTCGGTTGTGAATCCCTTCATCTACGCCTACCGTATCCGCGAGTTCCGCCAGACCTTCCGCAAGATCATTCGCAGCCACGTCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGTGCCCGGGTCTTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCCGTCTCAACGGCCACCCGCCAGGAGTGTGGGCCAACGGCAGTGCTCCCCACCCTGAGCGGAGGCCCAATGGCTATGCCCTGGGGCTGGTGAGTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTCCCAGACGTGGAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGCCCCCTGGCCTAGATGACCCCCTGGCCCAGGATGGAGCAGGAGTGTCCTGA |
| sequence of protein | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS | |
| Database link | RefSeq | NM_000675 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013] |
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