Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU002797 |
| Korean Unigene Clone | IRAT-30-B01 | |
| Original Clone | IRAK-47-E09 | |
| Vector | pBluescriptR | |
| Gene | INHBB | |
| Gene Description | inhibin subunit beta B | |
| Clone sequence size | 2809 (bp) | |
| Fullness | F | |
| Mutation | 168,1029 | |
| Amino acid - mutation | CCG(P)-> CAG(Q),GGC(G)-> AGC(S) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 2809 |
| Sequence | ACTCGGCTCGCCTCGCGGCGGGCGCCCTCGTCGCCAGCGGCGCAC CATGGACGGGCTGCCCGGTCGGGCGCTGGGGGCCGCCTGCCTTCT GCTGCTGGCGGCCGGCTGGCTGGGGCCTGAGGCCTGGGGCTCACC CACGCCCCCGCCGACGCCTGCCGCGCAGCCGCCACCCCCGCCACC CGGATCCCCGGGTGGCTCGCAGGACACCTGTACGTCGTGCGGCGG CTTCCGGCGGCCAGAGGAGCTCGGCCGAGTGGACGGCGACTTCCT GGAGGCGGTGAAGCGGCACATCTTGAGCCGCCTGCAGATGCGGGG CCGGCCCAACATCACGCACGCCGTGCCTAAGGCCGCCATGGTCAC GGCCCTGCGCAAGCTGCACGCGGGCAAGGTGCGCGAGGACGGCCG CGTGGAGATCCCGCACCTCGACGGCCACGCCAGCCCGGGCGCCGA CGGCCAGGAGCGCGTTTCCGAAATCATCAGCTTCGCCGAGACAGA TGGCCTCGCCTCCTCCCGGGTCCGCCTATACTTCTTCATCTCCAA CGAAGGCAACCAGAACCTGTTTGTGGTCCAGGCCAGCCTGTGGCT TTACCTGAAACTCCTGCCCTACGTCCTGGAGAAGGGCAGCCGGCG GAAGGTGCGGGTCAAAGTGTACTTCCAGGAGCAGGGCCACGGTGA CAGGTGGAACATGGTGGAGAAGAGGGTGGACCTCAAGCGCAGCGG CTGGCATACCTTCCCACTCACGGAGGCCATCCAGGCCTTGTTTGA GCGGGGCGAGCGGCGACTCAACCTAGACGTGCAGTGTGACAGCTG CCAGGAGCTGGCCGTGGTGCCGGTGTTCGTGGACCCAGGCGAAGA GTCGCACCGGCCCTTTGTGGTGGTGCAGGCTCGGCTGGGCGACAG CAGGCACCGCATTCGCAAGCGAGGCCTGGAGTGCGATGGCCGGAC CAACCTCTGTTGCAGGCAACAGTTCTTCATTGACTTCCGCCTCAT CGGCTGGAACGACTGGATCATAGCACCCACCAGCTACTACGGGAA CTACTGTGAGGGCAGCTGCCCAGCCTACCTGGCAGGGGTCCCCGG CTCTGCCTCCTCCTTCCACACGGCTGTGGTGAACCAGTACCGCAT GCGGGGTCTGAACCCCGGCACGGTGAACTCCTGCTGCATTCCCAC CAAGCTGAGCACCATGTCCATGCTGTACTTCGATGATGAGTACAA CATCGTCAAGCGGGACGTGCCCAACATGATTGTGGAGGAGTGCGG CTGCGCCTGACAGTGCAAGGCAGGGGCACGGTGGTGGGGCACGGA GGGCAGTCCCGGGTGGGCTTCTTCCAGCCCCCGCGGGAACGGGGG TACACGGTGGGCTGAGTACAGTCATTCTGTTGGGCTGTGGAGATA GTGCCAGGGTGCGGCCTGAGATATTTTTCTACAGCTTCATAGAGC AACCAGTCAAAACCAGAGCGAGAACCCTCAACTGACATGAAATAC TTTAAAATGCACACGTAGCCACGCACAGCCAGACGCATCCTGCCA CCCACACAGCAGCCTCCAGGATACCAGCAAATGGATGCGGTGACA AATGGCAGCTTAGCTACAAATGCCTGTCAGTCGGAGAGAATGGGG TGAGCAGCCACCATTCCCACAAGCTGGCCCGGCCACTCTGAATTG CGCCTTCCGAGCACACATAAAAGCACAAAGACAGAGACGCAGAGA GAGAGAGAGAGCCACGGAGAGGAAAAGCAGATGCAGGGGTGGGGA GCGCAGCTCGGCGGAGGCTGCGTGTGCCCCGTGGCTTTTACCAGG CCTGCTCTGCCTGGCTCGATGTCTGCTTCTTCCCCAGCCTGGGAT CCTTCGTGCTTCAAGGCCTGGGGAGCCTGTCCTTCCATGCCCTTG TCGAGGGAAAGAGACCCAGAAAGGACACAACCCGTCAGAGACCTG GGAGCAGGGGCAATGACCGTTTGACTGTTTGTGGCTTGGGCCTCT GACATGACTTATGTGTGTGTGTGTTTTTGGGGTGGGGAGGGAGAG AGAGAAGAGGGGGCTAAATTTGATGCTTTAACTGATCTCCAACAG TTGACAGGTCATCCTTGCCAGTTGTATAACTGAAAAAGGACTTTT CTACCAGGTATGACCTTTTAAGTGAAAATCTGAATTGTTCTAAAT GGAAAGAAAAAAAGTTGCAATCTGTGCCCTTCATTGGGGACATTC CTCTAGGACTGGTTTGGGGACGGGTGGGAGTGACCCCTAGGCAAG GGGATGAGACCGCAGGAGGAAATGGCGGGGAGGAGGCATTCTTGA ACTGCTGAGGATGGGGGGTGTCCCCTCAGCGGAGGCCAAGGGAGG GGAGCAGCCTAGTTGGTCTTGGAGAGATGGGGAAGGCTTTCAGCT GATTTGCAGAAGTTGCCCATGTGGGCCCCAGCCATCAGGGCTGGC CGTGGACGTGGCCCCTGCCCACTCACCTGCCCGCCTGCCCGCCCG CCAGCATAGCACTTGCAGACCTGCCTGAACGCACATGACATAGCA CTTGCCGATCTGCGTGTGTCCAGAAGTGGCCCTTGGCCGAGCGCC GAACTCGCTCGCCCTCTAGATGTCCAAGTGCCACGTGAACTATGC AATTTAAAGGGTTGACCCACACTAGACGAAACTGGACTCGTACGA CTCTTTTTATATTTTTTATACTTGAAATGAAATCCTTTGCTTCTT TTTTAAGCGAATGATTGCTTTTAATGTTTGCACTGATTTAGTTGC ATGATTAGTCAGAAACTGCCATTTGAAAAAAAGTTATTTTTATAG CAGCAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 2 | |||||||||||
| Location | 2cen-q13 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_002193 | |||||||||||
| KEGG Genes | 3625 | ||||||||||||
| GeneCard | INHBB |
| sequence | sequence of CDS | ATGGACGGGCTGCCCGGTCGGGCGCTGGGGGCCGCCTGCCTTCTGCTGCTGGCGGCCGGCTGGCTGGGGCCTGAGGCCTGGGGCTCACCCACGCCCCCGCCGACGCCTGCCGCGCCGCCGCCACCCCCGCCACCCGGATCCCCGGGTGGCTCGCAGGACACCTGTACGTCGTGCGGCGGCTTCCGGCGGCCAGAGGAGCTCGGCCGAGTGGACGGCGACTTCCTGGAGGCGGTGAAGCGGCACATCTTGAGCCGCCTGCAGATGCGGGGCCGGCCCAACATCACGCACGCCGTGCCTAAGGCCGCCATGGTCACGGCCCTGCGCAAGCTGCACGCGGGCAAGGTGCGCGAGGACGGCCGCGTGGAGATCCCGCACCTCGACGGCCACGCCAGCCCGGGCGCCGACGGCCAGGAGCGCGTTTCCGAAATCATCAGCTTCGCCGAGACAGATGGCCTCGCCTCCTCCCGGGTCCGCCTATACTTCTTCATCTCCAACGAAGGCAACCAGAACCTGTTTGTGGTCCAGGCCAGCCTGTGGCTTTACCTGAAACTCCTGCCCTACGTCCTGGAGAAGGGCAGCCGGCGGAAGGTGCGGGTCAAAGTGTACTTCCAGGAGCAGGGCCACGGTGACAGGTGGAACATGGTGGAGAAGAGGGTGGACCTCAAGCGCAGCGGCTGGCATACCTTCCCACTCACGGAGGCCATCCAGGCCTTGTTTGAGCGGGGCGAGCGGCGACTCAACCTAGACGTGCAGTGTGACAGCTGCCAGGAGCTGGCCGTGGTGCCGGTGTTCGTGGACCCAGGCGAAGAGTCGCACCGGCCCTTTGTGGTGGTGCAGGCTCGGCTGGGCGACAGCAGGCACCGCATTCGCAAGCGAGGCCTGGAGTGCGATGGCCGGACCAACCTCTGTTGCAGGCAACAGTTCTTCATTGACTTCCGCCTCATCGGCTGGAACGACTGGATCATAGCACCCACCGGCTACTACGGGAACTACTGTGAGGGCAGCTGCCCAGCCTACCTGGCAGGGGTCCCCGGCTCTGCCTCCTCCTTCCACACGGCTGTGGTGAACCAGTACCGCATGCGGGGTCTGAACCCCGGCACGGTGAACTCCTGCTGCATTCCCACCAAGCTGAGCACCATGTCCATGCTGTACTTCGATGATGAGTACAACATCGTCAAGCGGGACGTGCCCAACATGATTGTGGAGGAGTGCGGCTGCGCCTGA |
| sequence of protein | MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPTPAAPPPPPPPGSPGGSQDTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNMVEKRVDLKRSGWHTFPLTEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA | |
| Database link | RefSeq | NM_002193 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008] |
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