Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | KU013038 |
| Korean Unigene Clone | UG-0300-A11 | |
| Original Clone | L15CKK1-46-E11 | |
| Vector | pCNS-D2 | |
| Gene | IL1B | |
| Gene Description | interleukin 1 beta | |
| Clone sequence size | 1528 (bp) | |
| Fullness | F | |
| Mutation | 505 | |
| Amino acid - mutation | TAT(Y)-> TAG(Stop) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 1528 |
| Sequence | AAAAAAAAAAAAACCAAACCTCTTCGAGGCACAAGGCACAACAGG CTGCTCTGGGATTCTCTTCAGCCAATCTTCATTGCTCAAGTGTCT GAAGCAGCCATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATG GCTTATTACAGTGGCAATGAGGATGACTTGTTCTTTGAAGCTGAT GGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGACCTCTGC CCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTAC AGCAAGGGCTTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGAC AAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTCCAGGAG AATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAAGAACCT ATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCA CCTGTACGATCACTGAACTGCACGCTCCGGGACTCACAGCAAAAA AGCTTGGTGATGTCTGGTCCATAGGAACTGAAAGCTCTCCACCTC CAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATGTCCTTT GTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGC CTCAAGGAAAAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGAT AAGCCCACTCTACAGCTGGAGAGTGTAGATCCCAAAAATTACCCA AAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATAGAAATC AATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTAC ATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGG ACCAAAGGCGGCCAGGATATAACTGACTTCACCATGCAATTTGTG TCTTCCTAAAGAGAGCTGTACCCAGAGAGTCCTGTGCTGAATGTG GACTCAATCCCTAGGGCTGGCAGAAAGGGAACAGAAAGGTTTTTG AGTACGGCTATAGCCTGGACTTTCCTGTTGTCTACACCAATGCCC AACTGCCTGCCTTAGGGTAGTGCTAAGAGGATCTCCTGTCCATCA GCCAGGACAGTCAGCTCTCTCCTTTCAGGGCCAATCCCCAGCCCT TTTGTTGAGCCAGGCCTCTCTCACCTCTCCTACTCACTTAAAGCC CGCCTGACAGAAACCACGGCCACATTTGGTTCTAAGAAACCCTCT GTCATTCGCTCCCACATTCTGATGAGCAACCGCTTCCCTATTTAT TTATTTATTTGTTTGTTTGTTTTATTCATTGGTCTAATTTATTCA AAGGGGGCAAGAAGTAGCAGTGTCTGTAAAAGAGCCTAGTTTTTA ATAGCTATGGAATCAATTCAATTTGGACTGGTGTGCTCTCTTTAA ATCAAGTCCTTTAATTAACACTGAAAATATATAAGCTCAGATTAT TTAAATGGGAATATTTATAAATGAGCAAATATCATACTGTTCAAT GGTTCTGAAATAAACTTCACTGAAAAAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 2 | |||||||||||
| Location | 2q14 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_000576 | |||||||||||
| KEGG Genes | 3553 | ||||||||||||
| GeneCard | IL1B |
| sequence | sequence of CDS | ATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGATGACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGACCTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGCTTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAAGAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGATCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATATGAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATGTCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAAAAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGTGTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATAGAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACTGACTTCACCATGCAATTTGTGTCTTCCTAA |
| sequence of protein | MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS | |
| Database link | RefSeq | NM_000576 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] |
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