Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | KU014116 |
| Korean Unigene Clone | UG-0293-H12 | |
| Original Clone | L15CKK1-4-B07 | |
| Vector | pCNS-D2 | |
| Gene | PLAT | |
| Gene Description | plasminogen activator, tissue type | |
| Clone sequence size | 2849 (bp) | |
| Fullness | F | |
| Mutation | Large_Insertion | |
| Amino acid - mutation | ||
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 2849 |
| Sequence | AAAAAACGGCCTGCCTCAGCTCCCTCATGGCCCTGTCCACTGAGC ATCCTCCCGCCACACAGAAACCCGCCCAGCCGGGGCCACCGACCC CACCCCCTGCCTGGAAACTTAAAGGAGGCCGGAGCTGTGGGGAGC TCAGAGCTGAGATCCTACAGGAGTCCAGGGCTGGAGAGAAAACCT CTGCGAGGAAAGGGAAGGAGCAAGCCGTGAATTTAAGGGACGCTG TGAAGCAATCATGGATGCAATGAAGAGAGGGCTCTGCTGTGTGCT GCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGAAATCCA TGCCCGATTCAGAAGAGGAGCCAGATCTTACCAAGTGATCTGCAG AGATGAAAAAACGCAGATGATATACCAGCAACATCAGTCATGGCT GCGCCCTGTGCTCAGAAGCAACCGGGTGGAATATTGCTGGTGCAA CAGTGGCAGGGCACAGTGCCACTCAGTGCCTGTCAAAAGTTGCAG CGAGCCAAGGTGTTTCAACGGGGGCACCTGCCAGCAGGCCCTGTA CTTCTCAGATTTCGTGTGCCAGTGCCCCGAAGGATTTGCTGGGAA GTGCTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACCAGGG CATCAGCTACAGGGGCACGTGGAGCACAGCGGAGAGTGGCGCCGA GTGCACCAACTGGAACAGCAGCGCGTTGGCCCAGAAGCCCTACAG CGGGCGGAGGCCAGACGCCATCAGGCTGGGCCTGGGGAACCACAA CTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGT CTTTAAGGCGGGGAAGTACAGCTCAGAGTTCTGCAGCACCCCTGC CTGCTCTGAGGGAAACAGTGACTGCTACTTTGGGAATGGGTCAGC CTACCGTGGCACGCACAGCCTCACCGAGTCGGGTGCCTCCTGCCT CCCGTGGAATTCCATGATCCTGATAGGCAAGGTTTACACAGCACA GAACCCCAGTGCCCAGGCACTGGGCCTGGGCAAACATAATTACTG CCGGAATCCTGATGGGGATGCCAAGCCCTGGTGCCACGTGCTGAA GAACCGCAGGCTGACGTGGGAGTACTGTGATGTGCCCTCCTGCTC CACCTGCGGCCTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAA AGGAGGGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGC CATCTTTGCCAAGCCCAGCCTCAGTTTCGCATCAAAGGAGGGCTC TTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCATCTTTGCC AAGCACAGGAGGTCGCCCGGAGAGCGGTTCCTGTGCGGGGGCATA CTCATCAGCTCCTGCTGGATTCTCTCTGCCGCCCACTGCTTCCAG GAGAGGTTTCCGCCCCACCACCTGACGGTGATCTTGGGCAGAACA TACCGGGTGGTCCCTGGCGAGGAGGAGCAGAAATTTGAAGTCGAA AAATACATTGTCCATAAGGAATTCGATGATGACACTTACGACAAT GACATTGCGCTGCTGCAGCTGAAATCGGATTCGTCCCGCTGTGCC CAGGAGAGCAGCGTGGTCCGCACTGTGTGCCTTCCCCCGGCGGAC CTGCAGCTGCCGGACTGGACGGAGTGTGAGCTCTCCGGCTACGGC AAGCATGAGGCCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAG GCTCATGTCAGACTGTACCCATCCAGCCGCTGCACATCACAACAT TTACTTAACAGAACAGTCACCGACAACATGCTGTGTGCTGGAGAC ACTCGGAGCGGCGGGCCCCAGGCAAACTTGCACGACGCCTGCCAG GGCGATTCGGGAGGCCCCCTGGTGTGTCTGAACGATGGCCGCATG ACTTTGGTGGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAG GATGTCCCGGGTGTGTACACCAAGGTTACCAACTACCTAGACTCG ATTCGTGACAACATGCGACCGTGACCAGGAACACCCGACTCCTCA AAAGCAAATGAGATCCCGCCTCTTCTTCTTCAGAAGACACTGCAA AGGCGCAGTGCTTCTCTACAGACTTCTCCAGACCCACCACACCGC AGAAGCGGGACGAGACCCTACAGGAGAGGGAAGAGTGCATTTTCC CAGATACTTCCCATTTTGGAAGTTTTCAGGACTTGGTCTGATTTC AGGATACTCTGTCAGATGGGAAGACATGAATGCACACTAGCCTCT CCAGGAATGCCTCCTCCCTGGGCAGAAAGTGGCCATGCCACCCTG TTTTCAGCTAAAGCCCAACCTCCTGACCTGTCACCGTGAGCAGCT TTGGAAACAGGACCACAAAAATGAAAGCATGTCTCAATAGTAAAA GATAACAAGATCTTTCAGGAAAGACGGATTGCATTAGAAATAGAC AGTATATTTATAGTCACAAGAGCCCAGCAGGGCCTCAAAGTTGGG GCAGGCTGGCTGGCCCGTCATGTTCCTCAAAAGCACCCTTGACGT CAAGTCTCCTTCCCCTTTCCCCACTCCCTGGCTCTCAGAAGGTAT TCCTTTTGTGTACAGTGTGTAAAGTGTAAATCCTTTTTCTTTATA AACTTTAGAGTAGCATGAGAGAATTGTATCATTTGTGTACAGTGT GTAAGTGTAAATCCTTTTTCTTTATAAACTTTAGAGTAGCACGAT AGAATTGTATCATTTGAACAACTAGGCTTCAGCATATTTATAGCA ATCCATGTTAGTTTTTACTTTCTGTTGCCACAACCCTGTTTTATA CTGTACTTAATAAATTCAGATATATTTTTCACAGTTTTTCCAAAA AAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 8 | |||||||||||
| Location | 8p12 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_033011 | |||||||||||
| KEGG Genes | 5327 | ||||||||||||
| GeneCard | PLAT |
| sequence | sequence of CDS | ATGGATGCAATGAAGAGAGGGCTCTGCTGTGTGCTGCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGAAATCCATGCCCGATTCAGAAGAGGAGCCAGATCTTACCAAGGTTGCAGCGAGCCAAGGTGTTTCAACGGGGGCACCTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCCCCGAAGGATTTGCTGGGAAGTGCTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACCAGGGCATCAGCTACAGGGGCACGTGGAGCACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAACAGCAGCGCGTTGGCCCAGAAGCCCTACAGCGGGCGGAGGCCAGACGCCATCAGGCTGGGCCTGGGGAACCACAACTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTCTTTAAGGCGGGGAAGTACAGCTCAGAGTTCTGCAGCACCCCTGCCTGCTCTGAGGGAAACAGTGACTGCTACTTTGGGAATGGGTCAGCCTACCGTGGCACGCACAGCCTCACCGAGTCGGGTGCCTCCTGCCTCCCGTGGAATTCCATGATCCTGATAGGCAAGGTTTACACAGCACAGAACCCCAGTGCCCAGGCACTGGGCCTGGGCAAACATAATTACTGCCGGAATCCTGATGGGGATGCCAAGCCCTGGTGCCACGTGCTGAAGAACCGCAGGCTGACGTGGGAGTACTGTGATGTGCCCTCCTGCTCCACCTGCGGCCTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAAAGGAGGGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCATCTTTGCCAAGCACAGGAGGTCGCCCGGAGAGCGGTTCCTGTGCGGGGGCATACTCATCAGCTCCTGCTGGATTCTCTCTGCCGCCCACTGCTTCCAGGAGAGGTTTCCGCCCCACCACCTGACGGTGATCTTGGGCAGAACATACCGGGTGGTCCCTGGCGAGGAGGAGCAGAAATTTGAAGTCGAAAAATACATTGTCCATAAGGAATTCGATGATGACACTTACGACAATGACATTGCGCTGCTGCAGCTGAAATCGGATTCGTCCCGCTGTGCCCAGGAGAGCAGCGTGGTCCGCACTGTGTGCCTTCCCCCGGCGGACCTGCAGCTGCCGGACTGGACGGAGTGTGAGCTCTCCGGCTACGGCAAGCATGAGGCCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAGGCTCATGTCAGACTGTACCCATCCAGCCGCTGCACATCACAACATTTACTTAACAGAACAGTCACCGACAACATGCTGTGTGCTGGAGACACTCGGAGCGGCGGGCCCCAGGCAAACTTGCACGACGCCTGCCAGGGCGATTCGGGAGGCCCCCTGGTGTGTCTGAACGATGGCCGCATGACTTTGGTGGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAGGATGTCCCGGGTGTGTACACCAAGGTTACCAACTACCTAGACTGGATTCGTGACAACATGCGACCGTGA |
| sequence of protein | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQGCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP | |
| Database link | RefSeq | NM_033011 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
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