Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | KU031247 |
| Korean Unigene Clone | UG-0331-E09 | |
| Original Clone | L18POOL1n1-11-F02 | |
| Vector | pT7T3Pac | |
| Gene | FAS | |
| Gene Description | Fas cell surface death receptor | |
| Clone sequence size | 1721 (bp) | |
| Fullness | F | |
| Mutation | Insertion | |
| Amino acid - mutation | ||
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 1721 |
| Sequence | TGTACCATGCTGGGCATCTGGACCCTCCTACCTCTGGTTCTTACG TCTGTTGCTAGATTATCGTCCAAAAGTGTTAATGCCCAAGTGACT GACATCAACTCCAAGGGATTGGAATTGAGGAAGACTGTTACTACA GTTGAGACTCAGAACTTGGAAGGCCTGCATCATGATGGCCAATTC TGCCATAAGCCCTGTCCTCCAGGTGAAAGGAAAGCTAGGGACTGC ACAGTCAATGGGGATGAACCAGACTGCGTGCCCTGCCAAGAAGGG AAGGAGTACACAGACAAAGCCCATTTTTCTTCCAAATGCAGAAGA TGTAGATTGTGTGATGAAGGACATGGCTTAGAAGTGGAAATAAAC TGCACCCGGACCCAGAATACCAAGTGCAGATGTAAACCAAACTTT TTTTGTAACTCTACTGTATGTGAACACTGTGACCCTTGCACCAAA TGTGAACATGGAATCATCAAGGAATGCACACTCACCAGCAACACC AAGTGCAAAGAGGAAGGATCCAGATCTAACTTGGGGGGTGGCTTT GTCTTCTTCTTTTGCCAATTCCACTAATTGTTTGGGTGAAGAGAA AGGAAGTACAGAAAACATGCAGAAAGCACAGAAAGGAAAACCAAG GTTCTCATGAATCTCCAACCTTAAATCCTGAAACAGTGGCAATAA ATTTATCTGATGTTGACTTGAGTAAATATATCACCACTATTGCTG GAGTCATGACACTAAGTCAAGTTAAAGGCTTTGTTCGAAAGAATG GTGTCAATGAAGCCAAAATAGATGAGATCAAGAATGACAATGTCC AAGACACAGCAGAACAGAAAGTTCAACTGCTTCGTAATTGGCATC AACTTCATGGAAAGAAAGAAGCGTATGACACATTGATTAAAGATC TCAAAAAAGCCAATCTTTGTACTCTTGCAGAGAAAATTCAGACTA TCATCCTCAAGGACATTACTAGTGACTCAGAAAATTCAAACTTCA GAAATGAAATCCAAAGCTTGGTCTAGAGTGAAAAACAACAAATTC AGTTCTGAGTATATGCAATTAGTGTTTGAAAAGATTCTTAATAGC TGGCTGTAAATACTGCTTGGTTTTTTACTGGGTACATTTTATCAT TTATTAGCGCTGAAGAGCCAACATATTTGTAGATTTTTAATATCT CATGATTCTGCCTCCAAGGATGTTTAAAATCTAGTTGGGAAAACA AACTTCATCAAGAGTAAATGCAGTGGCATGCTCTTCATCAAGAGT AAATGCAGTGGCATGCTAAGTACCCAAATAGGAGTGTATGCAGAG GATGAAAGATTAAGATTATGCTCTGGCATCTAACATATGATTCTG TAGTATGAATGTAATCAGTGTATGTTAGTACAAATGTCTATCCAC AGGCTAACCCCACTCTATGAATCAATAGAAGAAGCTATGACCTTT TGCTGAAATATCAGTTACTGAACAGGCAGGCCACTTTGCCTCTAA ATTACCTCTGATAATTCTAGAGATTTTACCATATTTCTAAACTTT GTTTATAACTCTGAGAAGATCATATTTATGTAAAGTATATGTATT TGAGTGCAGAATTTAAATAAGGCTCTACCTCAAAGACCTTTGCAC AGTTTATTGGTGTCATATTATACAATATTTCAATTGTGAATTCAC ATAGAAAACATTAAATTATAATGTTTGACTATTAAAAAAAAAAAA AAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 10 | |||||||||||
| Location | 10q24.1 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_000043 | |||||||||||
| KEGG Genes | 355 | ||||||||||||
| GeneCard | FAS |
| sequence | sequence of CDS | ATGCTGGGCATCTGGACCCTCCTACCTCTGGTTCTTACGTCTGTTGCTAGATTATCGTCCAAAAGTGTTAATGCCCAAGTGACTGACATCAACTCCAAGGGATTGGAATTGAGGAAGACTGTTACTACAGTTGAGACTCAGAACTTGGAAGGCCTGCATCATGATGGCCAATTCTGCCATAAGCCCTGTCCTCCAGGTGAAAGGAAAGCTAGGGACTGCACAGTCAATGGGGATGAACCAGACTGCGTGCCCTGCCAAGAAGGGAAGGAGTACACAGACAAAGCCCATTTTTCTTCCAAATGCAGAAGATGTAGATTGTGTGATGAAGGACATGGCTTAGAAGTGGAAATAAACTGCACCCGGACCCAGAATACCAAGTGCAGATGTAAACCAAACTTTTTTTGTAACTCTACTGTATGTGAACACTGTGACCCTTGCACCAAATGTGAACATGGAATCATCAAGGAATGCACACTCACCAGCAACACCAAGTGCAAAGAGGAAGGATCCAGATCTAACTTGGGGTGGCTTTGTCTTCTTCTTTTGCCAATTCCACTAATTGTTTGGGTGAAGAGAAAGGAAGTACAGAAAACATGCAGAAAGCACAGAAAGGAAAACCAAGGTTCTCATGAATCTCCAACTTTAAATCCTGAAACAGTGGCAATAAATTTATCTGATGTTGACTTGAGTAAATATATCACCACTATTGCTGGAGTCATGACACTAAGTCAAGTTAAAGGCTTTGTTCGAAAGAATGGTGTCAATGAAGCCAAAATAGATGAGATCAAGAATGACAATGTCCAAGACACAGCAGAACAGAAAGTTCAACTGCTTCGTAATTGGCATCAACTTCATGGAAAGAAAGAAGCGTATGACACATTGATTAAAGATCTCAAAAAAGCCAATCTTTGTACTCTTGCAGAGAAAATTCAGACTATCATCCTCAAGGACATTACTAGTGACTCAGAAAATTCAAACTTCAGAAATGAAATCCAAAGCTTGGTCTAG |
| sequence of protein | MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV | |
| Database link | RefSeq | NM_000043 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] |
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