Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | KU035143 |
| Korean Unigene Clone | UG-0367-H12 | |
| Original Clone | S13KMS5-48-E07 | |
| Vector | pCNS | |
| Gene | PLAU | |
| Gene Description | plasminogen activator, urokinase | |
| Clone sequence size | 549 (bp) | |
| Fullness | FC | |
| Mutation | - | |
| Amino acid - mutation | - | |
| Price | \55,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 549 |
| Sequence | ACAGTGCGGAGACCGCAGCCCCGGAGCCCGGGCCAGGGTCCACCT GTCCCCGCAGCGCCGGCTCGCGCCCTCCTGCCGCAGCCACCGAGC CGCCGTCTAGCGCCCCGACCTCGCCACCATGAGAGCCCTGCTGGC GCGCCTGCTTCTCTGCGTCCTGGTCGTGAGCGACTCCAAAGGCAG CAATGAACTTCATCAAGTTCCATCGAACTGTGACTGTCTAAATGG AGGAACATGTGTGTCCAACAAGTACTTCTCCAACATTCACTGGTG CAACTGCCCAAAGAAATTCGGAGGGCAGCACTGTGAAATAGATAA GTCAAAAACCTGCTATGAGGGGAATGGTCACTTTTACCGAGGAAA GGCCAGCACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTC TGCCACTGTCCTTCAGCAAACGTACCATGCCCACAGATCTGATGC TCTTCAGCTGGGCCTGGGGAAACATAATTACTGCAGGAACCCAGA CAACCGGAGGCGACCCTGGTGCTATGTGCAGGTGGGCCTAAAGCT GCTTGTCCA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 10 | |||||||||||
| Location | 10q22.2 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_002658 | |||||||||||
| KEGG Genes | 5328 | ||||||||||||
| GeneCard | PLAU |
| sequence | sequence of CDS | ATGAGAGCCCTGCTGGCGCGCCTGCTTCTCTGCGTCCTGGTCGTGAGCGACTCCAAAGGCAGCAATGAACTTCATCAAGTTCCATCGAACTGTGACTGTCTAAATGGAGGAACATGTGTGTCCAACAAGTACTTCTCCAACATTCACTGGTGCAACTGCCCAAAGAAATTCGGAGGGCAGCACTGTGAAATAGATAAGTCAAAAACCTGCTATGAGGGGAATGGTCACTTTTACCGAGGAAAGGCCAGCACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTCTGCCACTGTCCTTCAGCAAACGTACCATGCCCACAGATCTGATGCTCTTCAGCTGGGCCTGGGGAAACATAATTACTGCAGGAACCCAGACAACCGGAGGCGACCCTGGTGCTATGTGCAGGTGGGCCTAAAGCTGCTTGTCCAAGAGTGCATGGTGCATGACTGCGCAGATGGAAAAAAGCCCTCCTCTCCTCCAGAAGAATTAAAATTTCAGTGTGGCCAAAAGACTCTGAGGCCCCGCTTTAAGATTATTGGGGGAGAATTCACCACCATCGAGAACCAGCCCTGGTTTGCGGCCATCTACAGGAGGCACCGGGGGGGCTCTGTCACCTACGTGTGTGGAGGCAGCCTCATCAGCCCTTGCTGGGTGATCAGCGCCACACACTGCTTCATTGATTACCCAAAGAAGGAGGACTACATCGTCTACCTGGGTCGCTCAAGGCTTAACTCCAACACGCAAGGGGAGATGAAGTTTGAGGTGGAAAACCTCATCCTACACAAGGACTACAGCGCTGACACGCTTGCTCACCACAACGACATTGCCTTGCTGAAGATCCGTTCCAAGGAGGGCAGGTGTGCGCAGCCATCCCGGACTATACAGACCATCTGCCTGCCCTCGATGTATAACGATCCCCAGTTTGGCACAAGCTGTGAGATCACTGGCTTTGGAAAAGAGAATTCTACCGACTATCTCTATCCGGAGCAGCTGAAAATGACTGTTGTGAAGCTGATTTCCCACCGGGAGTGTCAGCAGCCCCACTACTACGGCTCTGAAGTCACCACCAAAATGCTGTGTGCTGCTGACCCACAGTGGAAAACAGATTCCTGCCAGGGAGACTCAGGGGGACCCCTCGTCTGTTCCCTCCAAGGCCGCATGACTTTGACTGGAATTGTGAGCTGGGGCCGTGGATGTGCCCTGAAGGACAAGCCAGGCGTCTACACGAGAGTCTCACACTTCTTACCCTGGATCCGCAGTCACACCAAGGAAGAGAATGGCCTGGCCCTCTGA |
| sequence of protein | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL | |
| Database link | RefSeq | NM_002658 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
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