Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU000923 |
| Korean Unigene Clone | IRAT-10-E11 | |
| Original Clone | IRAK-14-M23 | |
| Vector | pCMV-SPORT6 | |
| Gene | EDN1 | |
| Gene Description | endothelin 1 | |
| Clone sequence size | 1334 (bp) | |
| Fullness | F | |
| Mutation | 585,861 | |
| Amino acid - mutation | GAA(E)-> GAG(E),AAG(K)-> AAT(N) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 1334 |
| Sequence | CGCCGCGTGCGCCTGCAGACGCTCCGCTCGCTGCCTTCTCTCCTG GCAGGCGCTGCCTTTTCTCCCCGTTAAAGGGCACTTGGGCTGAAG GATCGCTTTGAGATCTGAGGAACCCGCAGCGCTTTGAGGGACCTG AAGCTGTTTTTCTTCGTTTTCCTTTGGGTTCAGTTTGAACGGGAG GTTTTTGATCCCTTTTTTTCAGAATGGATTATTTGCTCATGATTT TCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAAACAGCAG TCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGA AACCCACTCCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCT GCTCCTGCTCGTCCCTGATGGATAAAGAGTGTGTCTACTTCTGCC ACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTTGTTCCGT ATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTAC TTCCCACAAAGGCAACAGACCGTGAGAATAGATGCCAATGTGCTA GCCAAAAAGACAAGAAGTGCTGGAATTTTTGCCAAGCAGGAAAAG AACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAATAATCATA AGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATC AGCAGTTAGTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAAC ACCTAAGACAAACCAGGTCGGAGACCATGAGAAACAGCGTCAAAT CATCTTTTCATGATCCCAAGCTGAAAGGCAATCCCTCCAGAGAGC GTTATGTGACCCACAACCGAGCACATTGGTGACAGACCTTCGGGG CCTGTCTGAAGCCATAGCCTCCACGGAGAGCCCTGTGGCCGACTC TGCACTCTCCACCCTGGCTGGGATCAGAGCAGGAGCATCCTCTGC TGGTTCCTGACTGGCAAAGGACCAGCGTCCTCGTTCAAAACATTC CAAGAAAGGTTAAGGAGTTCCCCCAACCATCTTCACTGGCTTCCA TCAGTGGTAACTGCTTTGGTCTCTTCTTTCATCTGGGGATGACAA TGGACCTCTCAGCAGAAACACACAGTCACATTCGAATTCGGGTGG CATCCTCCGGAGAGAGAGAGAGGAAGGAGATTCCACACAGGGGTG GAGTTTCTGACGAAGGTCCTAAGGGAGTGTTTGTGTCTGACTCAG GCGCCTGGCACATTTCAGGGAGAAACTCCAAAGTCCACACAAAGA TTTTCTAAGGAATGCACAAATTGAAAACACACTCAAAAGACAAAC ATGCAAGTAAAGAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 6 | |||||||||||
| Location | 6p24.1 | ||||||||||||
| Strand |
|
||||||||||||
| Database links | RefSeq | NM_001955 | |||||||||||
| KEGG Genes | 1906 | ||||||||||||
| GeneCard | EDN1 |
| sequence | sequence of CDS | ATGGATTATTTGCTCATGATTTTCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAAACAGCAGTCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGAAACCCACTCCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCTGCTCCTGCTCGTCCCTGATGGATAAAGAGTGTGTCTACTTCTGCCACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTTGTTCCGTATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTACTTCCCACAAAGGCAACAGACCGTGAAAATAGATGCCAATGTGCTAGCCAAAAAGACAAGAAGTGCTGGAATTTTTGCCAAGCAGGAAAAGAACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAATAATCATAAGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATCAGCAGTTAGTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAACACCTAAGACAAACCAGGTCGGAGACCATGAGAAACAGCGTCAAATCATCTTTTCATGATCCCAAGCTGAAAGGCAAGCCCTCCAGAGAGCGTTATGTGACCCACAACCGAGCACATTGGTGA |
| sequence of protein | MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW | |
| Database link | RefSeq | NM_001955 |
| UniProt | ||
| CCDS |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
|
| Disease | Summary |
| This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
|
|||||||||||
