Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU001405 |
| Korean Unigene Clone | IRAT-15-F01 | |
| Original Clone | IRAK-21-A09 | |
| Vector | pCMV-SPORT6 | |
| Gene | CD40 | |
| Gene Description | CD40 molecule | |
| Clone sequence size | 1157 (bp) | |
| Fullness | F | |
| Mutation | - | |
| Amino acid - mutation | - | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 1157 |
| Sequence | GTCAGCAGAGGCCTCGCTCGGGCGCCCAGTGGTCCTGCCGCCTGG TCTCACCTCGCTATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGG GGCTGCTTGCTGACCGCTGTCCATCCAGAACCACCCACTGCATGC AGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTGTGC CAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAA ACGGAATGCCTTCCTTGCGGTGAAAGCGAATTCCTAGACACCTGG AACAGAGAGACACACTGCCACCAGCACAAATACTGCGACCCCAAC CTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGACACC ATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGT GAGAGCTGTGTCCTGCACCGCTCATGCTCGCCCGGCTTTGGGGTC AAGCAGATTGCTACAGGGGTTTCTGATACCATCTGCGAGCCCTGC CCAGTCGGCTTCTTCTCCAATGTGTCATCTGCTTTCGAAAAATGT CACCCTTGGACAAGCTGTGAGACCAAAGACCTGGTTGTGCAACAG GCAGGCACAAACAAGACTGATGTTGTCTGTGGTCCCCAGGATCGG CTGAGAGCCCTGGTGGTGATCCCCATCATCTTCGGGATCCTGTTT GCCATCCTCTTGGTGCTGGTCTTTATCAAAAAGGTGGCCAAGAAG CCAACCAATAAGGCCCCCCACCCCAAGCAGGAACCCCAGGAGATC AATTTTCCCGACGATCTTCCTGGCTCCAACACTGCTGCTCCAGTG CAGGAGACTTTACATGGATGCCAACCGGTCACCCAGGAGGATGGC AAAGAGAGTCGCATCTCAGTGCAGGAGAGACAGTGAGGCTGCACC CACCCAGGAGTGTGGCCACGTGGGCAAACAGGCAGTTGGCCAGAG AGCCTGGTGCTGCTGCTGCTGTGGCGTGAGGGTGAGGGGCTGGCA CTGACTGGGCATAGCTCCCCGCTTCTGCCTGCACCCCTGCAGTTT GAGACAGGAGACCTGGCACTGGATGCAGAAACAGTTCACCTTGAA GAACCTCTCACTTCACCCTGGAGCCCATCCAGTCTCCCAACTTGT ATTAAAGACAGAGGCAGAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 20 | |||||||||||
| Location | 20q12-q13.2 | ||||||||||||
| Strand |
|
||||||||||||
| Database links | RefSeq | NM_001250 | |||||||||||
| KEGG Genes | 958 | ||||||||||||
| GeneCard | CD40 |
| sequence | sequence of CDS | ATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCAGAACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTGTGCCAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAAACGGAATGCCTTCCTTGCGGTGAAAGCGAATTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCACAAATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGACACCATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGTGAGAGCTGTGTCCTGCACCGCTCATGCTCGCCCGGCTTTGGGGTCAAGCAGATTGCTACAGGGGTTTCTGATACCATCTGCGAGCCCTGCCCAGTCGGCTTCTTCTCCAATGTGTCATCTGCTTTCGAAAAATGTCACCCTTGGACAAGCTGTGAGACCAAAGACCTGGTTGTGCAACAGGCAGGCACAAACAAGACTGATGTTGTCTGTGGTCCCCAGGATCGGCTGAGAGCCCTGGTGGTGATCCCCATCATCTTCGGGATCCTGTTTGCCATCCTCTTGGTGCTGGTCTTTATCAAAAAGGTGGCCAAGAAGCCAACCAATAAGGCCCCCCACCCCAAGCAGGAACCCCAGGAGATCAATTTTCCCGACGATCTTCCTGGCTCCAACACTGCTGCTCCAGTGCAGGAGACTTTACATGGATGCCAACCGGTCACCCAGGAGGATGGCAAAGAGAGTCGCATCTCAGTGCAGGAGAGACAGTGA |
| sequence of protein | MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ | |
| Database link | RefSeq | NM_001250 |
| UniProt | ||
| CCDS |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
|
| Disease | Summary |
| This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] |
|
|||||||||||
