Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU002822 |
| Korean Unigene Clone | IRAT-30-D02 | |
| Original Clone | IRAK-47-E18 | |
| Vector | pBluescriptR | |
| Gene | LIG4 | |
| Gene Description | DNA ligase 4 | |
| Clone sequence size | 3992 (bp) | |
| Fullness | F | |
| Mutation | - | |
| Amino acid - mutation | - | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 3992 |
| Sequence | CTTCTGGCGCCAGCTTCCGGCTTAGCGGCTGAGCTTCAGGCTTGA CGTCAGGAAACCATCAAGATCTCATTTTACAGCTGGGATTCTCTG GTTCACAGAGGTAACGGAGCTTGCCCGAGGCCAGTTAAACGAGAA GATTCATCACCGCTTTGATGGCTGCCTCACAAACTTCACAAACTG TTGCATCTCACGTTCCTTTTGCAGATTTGTGTTCAACTTTAGAAC GAATACAGAAAAGTAAAGGACGTGCAGAAAAAATCAGACACTTCA GGGAATTTTTAGATTCTTGGAGAAAATTTCATGATGCTCTTCATA AGAACCACAAAGATGTCACAGACTCTTTTTATCCAGCAATGAGAC TAATTCTTCCTCAGCTAGAAAGAGAGAGAATGGCCTATGGAATTA AAGAAACTATGCTTGCTAAGCTTTATATTGAGTTGCTTAATTTAC CTAGAGATGGAAAAGATGCCCTCAAACTTTTAAACTACAGAACAC CCACTGGAACTCATGGAGATGCTGGAGACTTTGCAATGATTGCAT ATTTTGTGTTGAAGCCAAGATGTTTACAGAAAGGAAGTTTAACCA TACAGCAAGTAAACGACCTTTTAGACTCAATTGCCAGCAATAATT CTGCTAAAAGAAAAGACCTAATAAAAAAGAGCCTTCTTCAACTTA TAACTCAGAGTTCAGCACTTGAGCAAAAGTGGCTTATACGGATGA TCATAAAGGATTTAAAGCTTGGTGTTAGTCAGCAAACTATCTTTT CTGTTTTTCATAATGATGCTGCTGAGTTGCATAATGTCACTACAG ATCTGGAAAAAGTCTGTAGGCAACTGCATGATCCTTCTGTAGGAC TCAGTGATATTTCTATCACTTTATTTTCTGCATTTAAACCAATGC TAGCTGCTATTGCAGATATTGAGCACATTGAGAAGGATATGAAAC ATCAGAGTTTCTACATAGAAACCAAGCTAGATGGTGAACGTATGC AAATGCACAAAGATGGAGATGTATATAAATACTTCTCTCGAAATG GATATAACTACACTGATCAGTTTGGTGCTTCTCCTACTGAAGGTT CTCTTACCCCATTCATTCATAATGCATTCAAAGCAGATATACAAA TCTGTATTCTTGATGGTGAGATGATGGCCTATAATCCTAATACAC AAACTTTCATGCAAAAGGGAACTAAGTTTGATATTAAAAGAATGG TAGAGGATTCTGATCTGCAAACTTGTTATTGTGTTTTTGATGTAT TGATGGTTAATAATAAAAAGCTAGGGCATGAGACTCTGAGAAAGA GGTATGAGATTCTTAGTAGTATTTTTACACCAATTCCAGGTAGAA TAGAAATAGTGCAGAAAACACAAGCTCATACTAAGAATGAAGTAA TTGATGCATTGAATGAAGCAATAGATAAAAGAGAAGAGGGAATTA TGGTAAAACAACCTCTATCCATCTACAAGCCAGACAAAAGAGGTG AAGGGTGGTTAAAAATTAAACCAGAGTATGTCAGTGGACTAATGG ATGAATTGGACATTTTAATTGTTGGAGGATATTGGGGTAAAGGAT CACGGGGTGGAATGATGTCTCATTTTCTGTGTGCAGTAGCAGAGA AGCCCCCTCCTGGTGAGAAGCCATCTGTGTTTCATACTCTCTCTC GTGTTGGGTCTGGCTGCACCATGAAAGAACTGTATGATCTGGGTT TGAAATTGGCCAAGTATTGGAAGCCTTTTCATAGAAAAGCTCCAC CAAGCAGCATTTTATGTGGAACAGAGAAGCCAGAAGTATACATTG AACCTTGTAATTCTGTCATTGTTCAGATTAAAGCAGCAGAGATCG TACCCAGTGATATGTATAAAACTGGCTGCACCTTGCGTTTTCCAC GAATTGAAAAGATAAGAGATGACAAGGAGTGGCATGAGTGCATGA CCCTGGACGACCTAGAACAACTTAGGGGGAAGGCATCTGGTAAGC TCGCATCTAAACACCTTTATATAGGTGGTGATGATGAACCACAAG AAAAAAAGCGGAAAGCTGCCCCAAAGATGAAGAAAGTTATTGGAA TTATTGAGCACTTAAAAGCACCTAACCTTACTAACGTTAACAAAA TTTCTAATATATTTGAAGATGTAGAGTTTTGTGTTATGAGTGGAA CAGATAGCCAGCCAAAGCCTGACCTGGAGAACAGAATTGCAGAAT TTGGTGGTTATATAGTACAAAATCCAGGCCCAGACACGTACTGTG TAATTGCAGGGTCTGAGAACATCAGAGTGAAAAACATAATTTTGT CAAATAAACATGATGTTGTCAAGCCTGCATGGCTTTTAGAATGTT TTAAGACCAAAAGCTTTGTACCATGGCAGCCTCGCTTTATGATTC ATATGTGCCCATCAACCAAAGAACATTTTGCCCGTGAATATGATT GCTATGGTGATAGTTATTTCATTGATACAGACTTGAACCAACTGA AGGAAGTATTCTCAGGAATTAAAAATTCTAACGAGCAGACTCCTG AAGAAATGGCTTCTCTGATTGCTGATTTAGAATATCGGTATTCCT GGGATTGCTCTCCTCTCAGTATGTTTCGACGCCACACCGTTTATT TGGACTCGTATGCTGTTATTAATGACCTGAGTACCAAAAATGAGG GGACAAGGTTAGCTATTAAAGCCTTGGAGCTTCGGTTTCATGGAG CAAAAGTAGTTTCTTGTTTAGCTGAGGGAGTGTCTCATGTAATAA TTGGGGAAGATCATAGTCGTGTTGCAGATTTTAAAGCTTTTAGAA GAACTTTTAAGAGAAAGTTTAAAATCCTAAAAGAAAGTTGGGTAA CTGATTCAATAGACAAGTGTGAATTACAAGAAGAAAACCAGTATT TGATTTAAAGCTAGGTTTCCTAGTGAGGAAAGCCTCTGATCTGGC AGACTCATTGCAGCAGGTGGTAATGATAAAATACTAAACTACATT TTATTTTTGTATCTTAAAAATCTATGCCTAAAAAGTATCATTACA TATAGGAAAACAATAATTTTAACTTTTAAGGTTGAAAAGACAATA GCCCAAAGCCAAGAAAGAAAAATTATCTTGAATGTAGTATTCAAT GATTTTTTATGATCAAGGTGAAATAAACAGTCTAAAGAAGAGGTG TTTTTATAATATCCATATAGAAATCTAGAATTTTTACTTAGATAC TAATAAAATACATTTAGAAACTTTTAAAGTCATGAAAAAGCATTA ACCTTCTAAACAGTATATTCTAAAAAGTCAAAACGTTAACAATAG TTTTTATCTAATAAAAGCACTGCAAGAAAATAGGGTAGAATTGTT ACAGCTGGACTTGTAAAAATATGTTTTTACTCAGGGTTTAAAATG TCCCATTTAAATATGAAATGTAAACAAATTTGTTTTTTAAGGTTA AGGCCAAATGTAACAATAAAACCCTGTCGATGGTTTTAGCTAAAT TAGAGGAAGTTGTATGAGACTTAATGATCTAAAAACTTAAAATTG AATTGGTTTGATTAAAAATAAAGCTTGCAATTTTAAAAGTAGCTC ACATTTAATTTCTTGTGTGAAATAGAACATGCTTTAAAGGAAGTA TTTTTATGTGAATTTGCATTCCAGTATAAATAGTATTCACAAAAA AGATTTTCCTAGATTTTATCTATTGAATAGGTGTCAATATGGCAT GCATATTGTAACTTTCATTAGAAATAAGTTGCTTTGACTTTTAAA AATGACATAGTTAGATTATTTAAAGTCAATGTATATAGTATATAT TATGTATGGATTTATATACCAAATTTTGGAATACAGCCTATCTCA TGACCATATTGAAATGTACGGAATTTGATCCATGCGATACTATGT GTGCATTATTTGAAAGTTATTGGAATTTTTATTCAAACCGTGGAA CAAATGTATGTGATTTTGTTATACTTCTTAATTTAAATAAAATAT TTAATGCACTATTAAAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 13 | |||||||||||
| Location | 13q33-q34 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_206937 | |||||||||||
| KEGG Genes | 3981 | ||||||||||||
| GeneCard | LIG4 |
| sequence | sequence of CDS | ATGGCTGCCTCACAAACTTCACAAACTGTTGCATCTCACGTTCCTTTTGCAGATTTGTGTTCAACTTTAGAACGAATACAGAAAAGTAAAGGACGTGCAGAAAAAATCAGACACTTCAGGGAATTTTTAGATTCTTGGAGAAAATTTCATGATGCTCTTCATAAGAACCACAAAGATGTCACAGACTCTTTTTATCCAGCAATGAGACTAATTCTTCCTCAGCTAGAAAGAGAGAGAATGGCCTATGGAATTAAAGAAACTATGCTTGCTAAGCTTTATATTGAGTTGCTTAATTTACCTAGAGATGGAAAAGATGCCCTCAAACTTTTAAACTACAGAACACCCACTGGAACTCATGGAGATGCTGGAGACTTTGCAATGATTGCATATTTTGTGTTGAAGCCAAGATGTTTACAGAAAGGAAGTTTAACCATACAGCAAGTAAACGACCTTTTAGACTCAATTGCCAGCAATAATTCTGCTAAAAGAAAAGACCTAATAAAAAAGAGCCTTCTTCAACTTATAACTCAGAGTTCAGCACTTGAGCAAAAGTGGCTTATACGGATGATCATAAAGGATTTAAAGCTTGGTGTTAGTCAGCAAACTATCTTTTCTGTTTTTCATAATGATGCTGCTGAGTTGCATAATGTCACTACAGATCTGGAAAAAGTCTGTAGGCAACTGCATGATCCTTCTGTAGGACTCAGTGATATTTCTATCACTTTATTTTCTGCATTTAAACCAATGCTAGCTGCTATTGCAGATATTGAGCACATTGAGAAGGATATGAAACATCAGAGTTTCTACATAGAAACCAAGCTAGATGGTGAACGTATGCAAATGCACAAAGATGGAGATGTATATAAATACTTCTCTCGAAATGGATATAACTACACTGATCAGTTTGGTGCTTCTCCTACTGAAGGTTCTCTTACCCCATTCATTCATAATGCATTCAAAGCAGATATACAAATCTGTATTCTTGATGGTGAGATGATGGCCTATAATCCTAATACACAAACTTTCATGCAAAAGGGAACTAAGTTTGATATTAAAAGAATGGTAGAGGATTCTGATCTGCAAACTTGTTATTGTGTTTTTGATGTATTGATGGTTAATAATAAAAAGCTAGGGCATGAGACTCTGAGAAAGAGGTATGAGATTCTTAGTAGTATTTTTACACCAATTCCAGGTAGAATAGAAATAGTGCAGAAAACACAAGCTCATACTAAGAATGAAGTAATTGATGCATTGAATGAAGCAATAGATAAAAGAGAAGAGGGAATTATGGTAAAACAACCTCTATCCATCTACAAGCCAGACAAAAGAGGTGAAGGGTGGTTAAAAATTAAACCAGAGTATGTCAGTGGACTAATGGATGAATTGGACATTTTAATTGTTGGAGGATATTGGGGTAAAGGATCACGGGGTGGAATGATGTCTCATTTTCTGTGTGCAGTAGCAGAGAAGCCCCCTCCTGGTGAGAAGCCATCTGTGTTTCATACTCTCTCTCGTGTTGGGTCTGGCTGCACCATGAAAGAACTGTATGATCTGGGTTTGAAATTGGCCAAGTATTGGAAGCCTTTTCATAGAAAAGCTCCACCAAGCAGCATTTTATGTGGAACAGAGAAGCCAGAAGTATACATTGAACCTTGTAATTCTGTCATTGTTCAGATTAAAGCAGCAGAGATCGTACCCAGTGATATGTATAAAACTGGCTGCACCTTGCGTTTTCCACGAATTGAAAAGATAAGAGATGACAAGGAGTGGCATGAGTGCATGACCCTGGACGACCTAGAACAACTTAGGGGGAAGGCATCTGGTAAGCTCGCATCTAAACACCTTTATATAGGTGGTGATGATGAACCACAAGAAAAAAAGCGGAAAGCTGCCCCAAAGATGAAGAAAGTTATTGGAATTATTGAGCACTTAAAAGCACCTAACCTTACTAACGTTAACAAAATTTCTAATATATTTGAAGATGTAGAGTTTTGTGTTATGAGTGGAACAGATAGCCAGCCAAAGCCTGACCTGGAGAACAGAATTGCAGAATTTGGTGGTTATATAGTACAAAATCCAGGCCCAGACACGTACTGTGTAATTGCAGGGTCTGAGAACATCAGAGTGAAAAACATAATTTTGTCAAATAAACATGATGTTGTCAAGCCTGCATGGCTTTTAGAATGTTTTAAGACCAAAAGCTTTGTACCATGGCAGCCTCGCTTTATGATTCATATGTGCCCATCAACCAAAGAACATTTTGCCCGTGAATATGATTGCTATGGTGATAGTTATTTCATTGATACAGACTTGAACCAACTGAAGGAAGTATTCTCAGGAATTAAAAATTCTAACGAGCAGACTCCTGAAGAAATGGCTTCTCTGATTGCTGATTTAGAATATCGGTATTCCTGGGATTGCTCTCCTCTCAGTATGTTTCGACGCCACACCGTTTATTTGGACTCGTATGCTGTTATTAATGACCTGAGTACCAAAAATGAGGGGACAAGGTTAGCTATTAAAGCCTTGGAGCTTCGGTTTCATGGAGCAAAAGTAGTTTCTTGTTTAGCTGAGGGAGTGTCTCATGTAATAATTGGGGAAGATCATAGTCGTGTTGCAGATTTTAAAGCTTTTAGAAGAACTTTTAAGAGAAAGTTTAAAATCCTAAAAGAAAGTTGGGTAACTGATTCAATAGACAAGTGTGAATTACAAGAAGAAAACCAGTATTTGATTTAA |
| sequence of protein | MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI | |
| Database link | RefSeq | NM_206937 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
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