Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU002866 |
| Korean Unigene Clone | IRAT-30-G10 | |
| Original Clone | IRAK-47-A06 | |
| Vector | pBluescriptR | |
| Gene | WT1 | |
| Gene Description | WT1 transcription factor | |
| Clone sequence size | 2473 (bp) | |
| Fullness | F | |
| Mutation | 708,747 | |
| Amino acid - mutation | ATA(I)-> ATG(M),CGA(R)-> CGG(R) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 2473 |
| Sequence | GCTTTCACCACTGCCCCTCCCGGGGGGACCTGAAGGAGAGGGTTT GAGGCCGGTCTTTGCCCGCCGAGGTCTGCGTGTCCGGTCTGGGAG GAGGCCTAGGAGGGCTCGCGGGCCACGGCATCCTTGGGCCCGAGT TCTGGGGTGCGGACGGACGTCTCGAGAGTGGGTGCCGCGACTCGG GACCCACGGCCCTCGCCGGGCACGGACAGTTGCGGAGCAGGGCTC TGAGGATTGTGCAGTGCCCTGGGTCCCTGCCTACTCCTGGGCTCA GGAATGGAGAAGGGTTACAGCACGGTCACCTTCGACGGGACGCCC AGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAAC CACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTG GGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCAC ACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGG ACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTT GAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAG GGAGTTGCTGCTGGGAGCTCCAGCTCAGTGAAATGGACAGAAGGG CAGAGCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACG CCCATCCTCTGCGGAGCCCAATACAGAATGCACACGCACGGTGTC TTCAGAGGCATTCAGGATGTGCGGCGTGTGCCTGGAGTAGCCCCG ACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTC ATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCC CACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATAC CAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGAC CAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTC CAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTG AAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGT CGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTA GTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAG CTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAG GCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCT CCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTC CAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGG AAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCC CTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGC CATTTGGTCTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCA TGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTG GGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGG CCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTT TCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGG CATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCT GCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAA GCTCATGCATTTCAAGCAGCTGAAGAAAGAATCAGAACTAACCAG TACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATT CAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCT GAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCAT ATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGG AATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCAT GCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAA GAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTT AAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAA ATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGT GTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTATTTTT TAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGT AAATATATGTCTGTTAATGATTTGCTCTTTGACAACTAAAATTAG GACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAG ATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTT GCTCTCAATTAAAGTCTATTCAAAAGGAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 11 | |||||||||||
| Location | 11p13 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_001198551 | |||||||||||
| KEGG Genes | 7490 | ||||||||||||
| GeneCard | WT1 |
| sequence | sequence of CDS | ATGGAGAAGGGTTACAGCACGGTCACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCCAACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGGGTGAGCAGCAGTACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGCCAGGCTTTGCTGCTGAGGACGCCCTACAGCAGTGACAATTTATACCAAATGACATCCCAGCTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGGAGTTGCTGCTGGGAGCTCCAGCTCAGTGAAATGGACAGAAGGGCAGAGCAACCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGA |
| sequence of protein | MEKGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL | |
| Database link | RefSeq | NM_001198551 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] |
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