Human cDNA
Basic Informations | Advanced Informations |
Clone information |
Clone ID | hMU002926 |
Korean Unigene Clone | IRAT-31-D10 | |
Original Clone | IRAK-47-J24 | |
Vector | pBluescriptR | |
Gene | PPM1D | |
Gene Description | protein phosphatase, Mg2+/Mn2+ dependent 1D | |
Clone sequence size | 2865 (bp) | |
Fullness | F | |
Mutation | 590 | |
Amino acid - mutation | TTG(L)-> TTT(F) | |
Price | \77,000 (부가세 포함가) |
Clone information |
5' end sequenced Length | 2865 |
Sequence | GGCGTCGTCGAAGATAAACAATAGTTGGCCGGCGAGCGCCTAGTG TGTCTCCCGCCGCCGGATTCGGCGGGCTGCGTGGGACCGGCGGGA TCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGAG CGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTAC TCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTC GCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCC GGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGT GGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTC GCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTT TTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTT TGCCCGGGAGCACTTTTGGGGTTTCATCAAGAAGCAGAAGGGTTT CACCTCGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGG CTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGGCGGAATG GCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGC CAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGT AGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGA TGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGA ACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGT AATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCG ACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCA GATTCCTTTTCTGGCAGTAGCAAGAGCACTTGGTGATTTGTGGAG CTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGA CACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTAT ATTGGGGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGC CATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGG TGAGCATGGACAATCTTGTGCCAAAATGCTTGTGAATCGAGCATT GGGCCGCTGGAGGCAGCGTATGCTCCGAGCAGATAACACTAGTGC CATAGTAATCTGCATCTCTCCAGAAGTGGACAATCAGGGAAACTT TACCAATGAAGATGAGTTATACCTGAACCTGACTGACAGCCCTTC CTATAATAGTCAAGAAACCTGTGTGATGACTCCTTCCCCATGTTC TACACCACCAGTCAAGTCACTGGAGGAGGATCCATGGCCAAGGGT GAATTCTAAGGACCATATACCTGCCCTGGTTCGTAGCAATGCCTT CTCAGAGAATTTTTTAGAGGTTTCAGCTGAGATAGCTCGAGAGAA TGTCCAAGGTGTAGTCATACCCTCAAAAGATCCAGAACCACTTGA AGAAAATTGCGCTAAAGCCCTGACTTTAAGGATACATGATTCTTT GAATAATAGCCTTCCAATTGGCCTTGTGCCTACTAATTCAACAAA CACTGTCATGGACCAAAAAAATTTGAAGATGTCAACTCCTGGCCA AATGAAAGCCCAAGAAATTGAAAGAACCCCTCCAACAAACTTTAA AAGGACATTAGAAGAGTCCAATTCTGGCCCCCTGATGAAGAAGCA TAGACGAAATGGCTTAAGTCGAAGTAGTGGTGCTCAGCCTGCAAG TCTCCCCACAACCTCACAGCGAAAGAACTCTGTTAAACTCACCAT GCGACGCAGACTTAGGGGCCAGAAGAAAATTGGAAATCCTTTACT TCATCAACACAGGAAAACTGTTTGTGTTTGCTGAAATGCATCTGG GAAATGAGGTTTTTCCAAACTTAGGATATAAGAGGGCTTTTTAAA TTTGGTGCCGATGTTGAACTTTTTTTAAGGGGAGAAAATTAAAAG AAATATACAGTTTGACTTTTTGGAATTCAGCAGTTTTATCCTGGC CTTGTACTTGCTTGTATTGTAAATGTGGATTTTGTAGATGTTAGG GTATAAGTTGCTGTAAAATTTGTGTAAATTTGTATCCACACAAAT TCAGTCTCTGAATACACAGTATTCAGAGTCTCTGATACACAGTAA TTGTGACAATAGGGCTAAATGTTTAAAGAAATCAAAAGAATCTAT TAGATTTTAGAAAAACATTTAAACTTTTTAAAATACTTATTAAAA AATTTGTATAAGCCACTTGTCTTGAAAACTGTGCAACTTTTTAAA GTAAATTATTAAGCAGACTGGAAAAGTGATGTATTTTCATAGTGA CCTGTGTTTCACTTAATGTTTCTTAGAGCCAAGTGTCTTTTAAAC ATTATTTTTTATTTCTGATTTCATAATTCAGAACTAAATTTTTCA TAGAAGTGTTGAGCCATGCTACAGTTAGTCTTGTCCCAATTAAAA TACTATGCAGTATCTCTTACATCAGTAGCATTTTTCTAAAACCTT AGTCATCAGATATGCTTACTAAATCTTCAGCATAGAAGGAAGTGT GTTTGCCTAAAACAATCTAAAACAATTCCCTTCTTTTTCATCCCA GACCAATGGCATTATTAGGTCTTAAAGTAGTTACTCCCTTCTCGT GTTTGCTTAAAATATGTGAAGTTTTCCTTGCTATTTCAATAACAG ATGGTGCTGCTAATTCCCAACATTTCTTAAATTATTTTATATCAT ACAGTTTTCATTGATTATATGGGTATATATTCATCTAATAAATCA GTGAACTGTTCCTCAAAAAAAAAAAAAAAA |
vector name | |
vector source | |
enzyme site(DNA insert) | |
sequencing primer | |
vector sequence | |
Gene Location | Chromosome | 17 | |||||||||||
Location | 17q23.2 | ||||||||||||
Strand |
|
||||||||||||
Database links | RefSeq | NM_003620 | |||||||||||
KEGG Genes | 8493 | ||||||||||||
GeneCard | PPM1D |
sequence | sequence of CDS | ATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGGTGAGCATGGACAATCTTGTGCCAAAATGCTTGTGAATCGAGCATTGGGCCGCTGGAGGCAGCGTATGCTCCGAGCAGATAACACTAGTGCCATAGTAATCTGCATCTCTCCAGAAGTGGACAATCAGGGAAACTTTACCAATGAAGATGAGTTATACCTGAACCTGACTGACAGCCCTTCCTATAATAGTCAAGAAACCTGTGTGATGACTCCTTCCCCATGTTCTACACCACCAGTCAAGTCACTGGAGGAGGATCCATGGCCAAGGGTGAATTCTAAGGACCATATACCTGCCCTGGTTCGTAGCAATGCCTTCTCAGAGAATTTTTTAGAGGTTTCAGCTGAGATAGCTCGAGAGAATGTCCAAGGTGTAGTCATACCCTCAAAAGATCCAGAACCACTTGAAGAAAATTGCGCTAAAGCCCTGACTTTAAGGATACATGATTCTTTGAATAATAGCCTTCCAATTGGCCTTGTGCCTACTAATTCAACAAACACTGTCATGGACCAAAAAAATTTGAAGATGTCAACTCCTGGCCAAATGAAAGCCCAAGAAATTGAAAGAACCCCTCCAACAAACTTTAAAAGGACATTAGAAGAGTCCAATTCTGGCCCCCTGATGAAGAAGCATAGACGAAATGGCTTAAGTCGAAGTAGTGGTGCTCAGCCTGCAAGTCTCCCCACAACCTCACAGCGAAAGAACTCTGTTAAACTCACCATGCGACGCAGACTTAGGGGCCAGAAGAAAATTGGAAATCCTTTACTTCATCAACACAGGAAAACTGTTTGTGTTTGCTGA |
sequence of protein | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC | |
Database link | RefSeq | NM_003620 |
UniProt | ||
CCDS |
|
Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
|
Disease | Summary |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] |
|
|||||||||||