Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU004052 |
| Korean Unigene Clone | IRAT-44-B08 | |
| Original Clone | IRAK-49-P15 | |
| Vector | pCMV-SPORT6 | |
| Gene | NPPB | |
| Gene Description | natriuretic peptide B | |
| Clone sequence size | 707 (bp) | |
| Fullness | F | |
| Mutation | - | |
| Amino acid - mutation | - | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 707 |
| Sequence | GGGCAGGTGGGAAGCAAACCCGGACGCATCGCAGCAGCAGCAGCA GCAGCAGAAGCAGCAGCAGCAGCCTCCGCAGTCCCTCCAGAGACA TGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCT TCTTGCATCTGGCTTTCCTGGGAGGTCGTTCCCACCCGCTGGGCA GCCCCGGTTCAGCCTCGGACTTGGAAACGTCCGGGTTACAGGAGC AGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAGC AGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTG TCTGGAAGTCCCGGGAGGTAGCCACCGAGGGCATCCGTGGGCACC GCAAAATGGTCCTCTACACCCTGCGGGCACCACGAAGCCCCAAGA TGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATCA GCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAAG AGGAAGTCCTGGCTGCAGACACCTGCTTCTGATTCCACAAGGGGC TTTTTCCTCAACCCTGTGGCCGCCTTTGAAGTGACTCATTTTTTT AATGTATTTATGTATTTATTTGATTGTTTTATATAAGATGGTTTC TTACCTTTGAGCACAAAATTTCCACGGTGAAATAAAGTCAACATT ATAAGCTTTAAAAAAAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 1 | |||||||||||
| Location | 1p36.2 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_002521 | |||||||||||
| KEGG Genes | 4879 | ||||||||||||
| GeneCard | NPPB |
| sequence | sequence of CDS | ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCTTTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACGTCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAGCAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGGGAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCACCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATCAGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA |
| sequence of protein | MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH | |
| Database link | RefSeq | NM_002521 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014] |
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