Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU005604 |
| Korean Unigene Clone | IRAU-02-C12 | |
| Original Clone | IRAL-01-G15 | |
| Vector | pOTB7 | |
| Gene | GRN | |
| Gene Description | granulin precursor | |
| Clone sequence size | 1858 (bp) | |
| Fullness | F | |
| Mutation | Large_INDEL | |
| Amino acid - mutation | ||
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 1858 |
| Sequence | GGCGAGAGGAAGCAGGGAGGAGAGTGATTTGAGTAGAAAAGAAAC ACAGCATTCCAGGCTGGCCCCACCTCTATATTGATAAGTAGCCAA TGGGAGCGGGTAGCCCTGATCCCTGGCCAATGGAAACTGAGGTAG GCGGGTCATCGCGCTGGGGTCTGTAGTCTGAGCGCTACCCGGTTG CTGCTGCCCAAGGACCGCGGAGTCGGACGCAGGCAGACCATGTGG ACCCTGGTGAGCTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGA ACGCGGTGCCCAGATGGTCAGTTCTGCCCTGTGGCCTGCTGCCTG GACCCCGGAGGAGCCAGCTACAGCTGCTGCCGTCCCCTTCTGGAC AAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCCTGCCAG GTTGATGCCCACTGCTCTGCCGGCCACTCCTGCATCTTTACCGTC TCAGGGACTTCCAGTTGCTGCCCCTTCCCAGAGGCCGTGGCATGC GGGGATGGCCATCACTGCTGCCCACGGGGCTTCCACTGCAGTGCA GACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCCGTGGGT GCCATCCAGTGCCCTGATAGTCAGTTCGAATGCCCGGACTTCTCC ACGTGCTGTGTTATGGTCGATGGCTCCTGGGGGTGCTGCCCCATG CCCCAGGCTTCCTGCTGTGAAGACAGGGTGCACTGCTGTCCGCAC GGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACACCCACG GGCACCCACCCCCTGGCAAAGAAGCTCCCTGCCCAGAGGACTAAC AGGGCAGTGGCCTTGTCCAGCTCGGTCATGTGTCCGGACGCACGG TCCCGGTGCCCTGATGGTTCTACCTGCTGTGAGCTGCCCAGTGGG AAGTATGGCTGCTGCCCAATGCCCAACGCCACCTGCTGCTCCGAT CACCTGCACTGCTGCCCCCAAGACACTGTGTGTGACCTGATCCAG AGTAAGTGCCTCTCCAAGGAGAACGCTACCACGGACCTCCTCACT AAGCTGCCTGCGCACACAGTGGGGGATGTGAAATGTGACATGGAG GTGAGCTGCCCAGATGGCTATACCTGCTGCCGTCTACAGTCGGGG GCCTGGGGCTGCTGCCCTTTTACCCAGGCTGTGTGCTGTGAGGAC CACATACACTGCTGTCCCGCGGGGTTTACGTGTGACACGCAGAAG GGTACCTGTGAACAGGGGCCCCACCAGGTGCCCTGGATGGAGAAG GCCCCAGCTCACCTCAGCCTGCCAGACCCACAAGCCTTGAAGAGA GATGTCCCCTGTGATAATGTCAGCAGCTGTCCCTCCTCCGATACC TGCTGCCGAGACAACCGACAGGGCTGGGCCTGCTGTCCCTACCGC CAGGGCGTCTGTTGTGCTGATCGGCGCCACTGCTGTCCTGCTGGC TTCCGCTGCGCAGCCAGGGGTACCAAGTGTTTGCGCAGGGAGGCC CCGCGCTGGGACGCCCCTTTGAGGGACCCAGCCTTGAGACAGCTG CTGTGAGGGACAGTACTGAAGACTCTGCAGCCCTCGGGACCCCAC TCGGAGGGTGCCCTCTGCTCAGGCCTCCCTAGCACCTCCCCCTAA CCAAATTCTCCCTGGACCCCATTCTGAGCTCCCCATCACCATGGG AGGTGGGGCCTCAATCTAAGGCCTTCCCTGTCAGAAGGGGGTTGT GGCAAAAGCCACATTACAAGCTGCCATCCCCTCCCCGTTTCAGTG GACCCTGTGGCCAGGTGCTTTTCCCTATCCACAGGGGTGTTTGTG TGTGTGCGCGTGTGCGTTTCAATAAAGTTTGTACACTTTCAAAAA AAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 17 | |||||||||||
| Location | 17q21.32 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_002087 | |||||||||||
| KEGG Genes | 2896 | ||||||||||||
| GeneCard | GRN |
| sequence | sequence of CDS | ATGTGGACCCTGGTGAGCTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGAACGCGGTGCCCAGATGGTCAGTTCTGCCCTGTGGCCTGCTGCCTGGACCCCGGAGGAGCCAGCTACAGCTGCTGCCGTCCCCTTCTGGACAAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCCTGCCAGGTTGATGCCCACTGCTCTGCCGGCCACTCCTGCATCTTTACCGTCTCAGGGACTTCCAGTTGCTGCCCCTTCCCAGAGGCCGTGGCATGCGGGGATGGCCATCACTGCTGCCCACGGGGCTTCCACTGCAGTGCAGACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCCGTGGGTGCCATCCAGTGCCCTGATAGTCAGTTCGAATGCCCGGACTTCTCCACGTGCTGTGTTATGGTCGATGGCTCCTGGGGGTGCTGCCCCATGCCCCAGGCTTCCTGCTGTGAAGACAGGGTGCACTGCTGTCCGCACGGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACACCCACGGGCACCCACCCCCTGGCAAAGAAGCTCCCTGCCCAGAGGACTAACAGGGCAGTGGCCTTGTCCAGCTCGGTCATGTGTCCGGACGCACGGTCCCGGTGCCCTGATGGTTCTACCTGCTGTGAGCTGCCCAGTGGGAAGTATGGCTGCTGCCCAATGCCCAACGCCACCTGCTGCTCCGATCACCTGCACTGCTGCCCCCAAGACACTGTGTGTGACCTGATCCAGAGTAAGTGCCTCTCCAAGGAGAACGCTACCACGGACCTCCTCACTAAGCTGCCTGCGCACACAGTGGGGGATGTGAAATGTGACATGGAGGTGAGCTGCCCAGATGGCTATACCTGCTGCCGTCTACAGTCGGGGGCCTGGGGCTGCTGCCCTTTTACCCAGGCTGTGTGCTGTGAGGACCACATACACTGCTGTCCCGCGGGGTTTACGTGTGACACGCAGAAGGGTACCTGTGAACAGGGGCCCCACCAGGTGCCCTGGATGGAGAAGGCCCCAGCTCACCTCAGCCTGCCAGACCCACAAGCCTTGAAGAGAGATGTCCCCTGTGATAATGTCAGCAGCTGTCCCTCCTCCGATACCTGCTGCCAACTCACGTCTGGGGAGTGGGGCTGCTGTCCAATCCCAGAGGCTGTCTGCTGCTCGGACCACCAGCACTGCTGCCCCCAGGGCTACACGTGTGTAGCTGAGGGGCAGTGTCAGCGAGGAAGCGAGATCGTGGCTGGACTGGAGAAGATGCCTGCCCGCCGGGCTTCCTTATCCCACCCCAGAGACATCGGCTGTGACCAGCACACCAGCTGCCCGGTGGGGCAGACCTGCTGCCCGAGCCTGGGTGGGAGCTGGGCCTGCTGCCAGTTGCCCCATGCTGTGTGCTGCGAGGATCGCCAGCACTGCTGCCCGGCTGGCTACACCTGCAACGTGAAGGCTCGATCCTGCGAGAAGGAAGTGGTCTCTGCCCAGCCTGCCACCTTCCTGGCCCGTAGCCCTCACGTGGGTGTGAAGGACGTGGAGTGTGGGGAAGGACACTTCTGCCATGATAACCAGACCTGCTGCCGAGACAACCGACAGGGCTGGGCCTGCTGTCCCTACCGCCAGGGCGTCTGTTGTGCTGATCGGCGCCACTGCTGTCCTGCTGGCTTCCGCTGCGCAGCCAGGGGTACCAAGTGTTTGCGCAGGGAGGCCCCGCGCTGGGACGCCCCTTTGAGGGACCCAGCCTTGAGACAGCTGCTGTGA |
| sequence of protein | MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL | |
| Database link | RefSeq | NM_002087 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] |
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