Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU006208 |
| Korean Unigene Clone | IRAU-08-F04 | |
| Original Clone | IRAL-04-B24 | |
| Vector | pOTB7 | |
| Gene | MMP2 | |
| Gene Description | matrix metallopeptidase 2 | |
| Clone sequence size | 3065 (bp) | |
| Fullness | F | |
| Mutation | 958,1429,1660,2086 | |
| Amino acid - mutation | GGG(G)-> GGC(G),GAT(D)-> GAC(D),ACG(T)-> ACA(T),TTC(F)-> TTT(F) | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 3065 |
| Sequence | CTCAGGCGGTGGCTGGAGGCTGCGCATCTGGGGCTTTAAACATAC AAAGGGATTGCCAGGACCTGCGGCGGCGGCGGCGGCGGCGGGGGC TGGGGCGCGGGGGCCGGACCATGAGCCGCTGAGCCGGGCAAACCC CAGGCCACCGAGCCAGCGGACCCTCGGAGCGCAGCCCTGCGCCGC GGAGCAGGCTCCAACCAGGCGGCGACGCGGCCACACGCACCGAGC CAGCGACCCCCGGGCGACGCGCGGGGCCAGGGAGCGCTACGATGG AGGCGCTAATGGCCCGGGGCGCGCTCACGGGTCCCCTGAGGGCGC TCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGT CGCCCATCATCAAGTTCCCCGGCGATGTCGCCCCCAAAACGGACA AAGAGTTGGCAGTGCAATACCTGAACACCTTCTATGGCTGCCCCA AGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGA TGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGA ATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATG TGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGA ACCAGATCACATACAGGATCATTGGCTACACACCTGATCTGGACC CAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGA GCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGG CAGACATCATGATCAACTTTGGCCGCTGGGAGCATGGCGATGGAT ACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCC CAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGC TATGGACCTTGGGAGAAGGCCAAGTGGTCCGTGTGAAGTATGGCA ACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCA AGGAGTACAACAGCTGCACTGATACCGGCCGCAGCGATGGCTTCC TCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACG GCTTCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCTG AAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCT ATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGT GCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCT GCCCTGAGACCGCCATGTCCACTGTTGGTGGGAACTCAGAAGGTG CCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGA GCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGA CCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTCTGCCCTG ACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCC ACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGG CACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGATG ACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTG ACCTTGGCACCGGCCCCACCCCCACACTGGGCCCTGTCACTCCTG AGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAGATCC GTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACTG TGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACAT TCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGGCCC CACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGA TCTACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGA CCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCT TTAACTGGAGCAAAAACAAGAAGACATACATCTTTGCTGGAGACA AATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGATCCTGGCT TTCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACC TGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCT TCAAGGGTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAAGA GCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGAG CTGGCCCTGGCTCCCACAGGCCCTTCCTCTCCACTGCCTTCGATA CACCGGGCCTGGAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAG CCGTGCCTTCAGCTCTACAGCTAATCAGCATTCTCACTCCTACCT GGTAATTTAAGATTCCAGAGAGTGGCTCCTCCCGGTGCCCAAGAA TAGATGCTGACTGTACTCCTCCCAGGCGCCCCTTCCCCCTCCAAT CCCACCAACCCTCAGAGCCACCCCTAAAGAGATCCTTTGATATTT TCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGCTGCCACACTTCA GGCTCTTCTCCTTTCACAACCTTCTGTGGCTCACAGAACCCTTGG AGCCAATGGAGACTGTCTCAAGAGGGCACTGGTGGCCCGACAGCC TGGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCCACTCCAG ACCCCTGGCTTTTCACTGCTGGCTGCCTTAGAACCTTTCTTACAT TAGCAGTTTGCTTTGTATGCACTTTGTTTTTTTCTTTGGGTCTTG TTTTTTTTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGACTC AGGTTGTCTGAAGTCACTGCACAGTGCATCTCAGCCCACATAGTG ATGGTTCCCCTGTTCACTCTACTTAGCATGTCCCTACCGAGTCTC TTCTCCACTGGATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAG CCCTCCCTGCCCCTCCCTTCAACCATTCCCCATGGGAAATGTCAA CAAGTATGAATAAAGACACCTACTGAGTGAAAAAAAAAAAAAAAA AAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 16 | |||||||||||
| Location | 16q12.2 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_004530 | |||||||||||
| KEGG Genes | 4313 | ||||||||||||
| GeneCard | MMP2 |
| sequence | sequence of CDS | ATGGAGGCGCTAATGGCCCGGGGCGCGCTCACGGGTCCCCTGAGGGCGCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGCGATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACACCTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTGGGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGAGAAGGCCAAGTGGTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGATACCGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGCCATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCAACTACGATGATGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGATGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGGCCCCACCCCCACGCTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACTGTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCTACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGA |
| sequence of protein | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC | |
| Database link | RefSeq | NM_004530 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
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