Human cDNA
Basic Informations | Advanced Informations |
Clone information |
Clone ID | hMU011047 |
Korean Unigene Clone | IRAU-59-A07 | |
Original Clone | IRAL-25-N20 | |
Vector | pOTB7 | |
Gene | MAP2K2 | |
Gene Description | mitogen-activated protein kinase kinase 2 | |
Clone sequence size | 1692 (bp) | |
Fullness | F | |
Mutation | 705,912 | |
Amino acid - mutation | GAC(D)-> GAT(D),ATC(I)-> ATA(I) | |
Price | \77,000 (부가세 포함가) |
Clone information |
5' end sequenced Length | 1692 |
Sequence | GCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTCGGCTACCCTCGGC CCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCC TGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAGGCGCCGACCGCTC CCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCC GGCCCGCGGAGCCCCGATGCTGGCCCGGAGGAAGCCGGTGCTGCC GGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTAC CAGCGAGGGCGCCTCCGAGGCAAACCTGGTGGACCTGCAGAAGAA GCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGA AGCCTTTCTCACCCAGAAAGCCAAGGTCGGCGAACTCAAAGACGA TGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGT GGTCACCAAAGTCCAGCACAGACCCTCGGGCCTCATCATGGCCAG GAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGAT CATCCGCGAGCTGCAGGTCCTGCACGAATGCAACTCGCCGTACAT CGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCAT TTGCATGGAACACATGGATGGCGGCTCCCTGGACCAGGTGCTGAA AGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCAT CGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAGCACCAGAT CATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAG AGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGCCAGCTCAT AGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGC TCCGGAGCGGTTGCAGGGCACACATTACTCGGTGCAGTCGGACAT CTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTA CCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCCATCTTTGG CCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTC GCCTCGGCCGAGGCCCCCCGGGCGCCCCGTCAGCGGTCACGGGAT GGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATAT TGTGAACGAGCCACCTCCTAAGCTGCCCAACGGTGTGTTCACCCC CGACTTCCAGGAGTTTGTCAATAAATGCCTCATCAAGAACCCAGC GGAGCGGGCGGACCTGAAGATGCTCACAAACCACACCTTCATCAA GCGGTCCGAGGTGGAAGAAGTGGATTTTGCCGGCTGGTTGTGTAA AACCCTGCGGCTGAACCAGCCCGGCACACCCACGCGCACCGCCGT GTGACAGTGGCCGGGCTCCCTGCGTCCCGCTGGTGACCTGCCCAC CGTCCCTGTCCATGCCCCGCCCTTCCAGCTGAGGACAGGCTGGCG CCTCCACCCACCCTCCTGCCTCACCCCTGCGGAGAGCACCGTGGC GGGGCGACAGCGCATGCAGGAACGGGGGTCTCCTCTCCTGCCCGT CCTGGCCGGGGTGCCTCTGGGGACGGGCGACGCTGCTGTGTGTGG TCTCAGAGGCTCTGCTTCCTTAGGTTACAAAACAAAACAGGGAGA GAAAAAGCAAAAAAAAAAAAAAAAAAA |
vector name | |
vector source | |
enzyme site(DNA insert) | |
sequencing primer | |
vector sequence | |
Gene Location | Chromosome | 19 | |||||||||||
Location | 19p13.3 | ||||||||||||
Strand |
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Database links | RefSeq | NM_030662 | |||||||||||
KEGG Genes | 5605 | ||||||||||||
GeneCard | MAP2K2 |
sequence | sequence of CDS | ATGCTGGCCCGGAGGAAGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGACGGCGGCTCCCTGGACCAGGTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAGCACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGCCAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAGGGCACACATTACTCGGTGCAGTCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCCATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGGCCCCCCGGGCGCCCCGTCAGCGGTCACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGCCACCTCCTAAGCTGCCCAACGGTGTGTTCACCCCCGACTTCCAGGAGTTTGTCAATAAATGCCTCATCAAGAACCCAGCGGAGCGGGCGGACCTGAAGATGCTCACAAACCACACCTTCATCAAGCGGTCCGAGGTGGAAGAAGTGGATTTTGCCGGCTGGTTGTGTAAAACCCTGCGGCTGAACCAGCCCGGCACACCCACGCGCACCGCCGTGTGA |
sequence of protein | MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV | |
Database link | RefSeq | NM_030662 |
UniProt | ||
CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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Disease | Summary |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] |
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