Human cDNA
| Basic Informations | Advanced Informations |
| Clone information |
Clone ID | hMU012458 |
| Korean Unigene Clone | IRAU-73-G02 | |
| Original Clone | IRAL-34-L10 | |
| Vector | pOTB7 | |
| Gene | CDKN2B | |
| Gene Description | cyclin dependent kinase inhibitor 2B | |
| Clone sequence size | 2377 (bp) | |
| Fullness | F | |
| Mutation | - | |
| Amino acid - mutation | - | |
| Price | \77,000 (부가세 포함가) |
| Clone information |
5' end sequenced Length | 2377 |
| Sequence | GTGAGGACTCCGCGACGCGTCCGCACCCTGCGGCCAGAGCGGCTT TGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCAAT CCAGGCGCGCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGC TAACGACCGGCCGCTCGGCCACTGCACGGGGCCCCAAGCCGCAGA AGGACGACGGGAGGGTAATGAAGCTGAGCCCAGGTCTCCTAGGAA GGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTGTC GTTAAGTTTACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTC TGGGGGCTGCGGAATGCGCGAGGAGAACAAGGGCATGCCCAGTGG GGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACT AGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAA CGGAGTCAACCGTTTCGGGAGGCGCGCGATCCAGGTCATGATGAT GGGCAGCGCCCGCGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA GCCCAACTGCGCAGACCCTGCCACTCTCACCCGACCGGTGCATGA TGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGTCGTCTGCC CGTGGACTTGGCCGAGGAGCGGGGCCACCGCGACGTTGCAGGGTA CCTGCGCACAGCCACGGGGGACTGACGCCAGGTTCCCCAGCCGCC CACAACGACTTTATTTTCTTACCCAATTTCCCACCCCCACCCACC TAATTCGATGAAGGCTGCCAACGGGGAGCGGCGGAAAGCCTGTAA GCCTGCAAGCCTGTCTGAGACTCACAGGAAGGAGGAGCCGACCGG GAATAACCTTCCATACATTTTTTTCTTTGTCTTATCTGGCCCTCG ACACTCACCATGAAGCGAAACACAGAGAAGCGGATTTCCAGGGAT ATTTAGGAGTGTGTGACATTCCAGGGGTCGTTTGCTTTTCAGGGT TTTCTGAGGGAAAGTGCATATGAAATCCTTGACTGGACCTGGTGG CTACGAATCTTCCGATGGATGAATCTCCCACTCCAGCGCTGAGTG GGAGAAGGCAGTGATTAGCACTTGGGTGACGGCAGTCGATGCGTT CACTCCAATGTCTGCTGAGGAGTTATGGTGAACCCACAACTTAGG CCCTAGCGGCAGAAAGGAAAACCTGAAGACTGAGGACAAAGTGGA GGAGGGCCGAGGTGGGCTTCAGTAAGTCCCCGGCGGCGCTTTAGT TTGAGCGCATGGCAAGTCACATGCGTAAACGACACTCTCTGGAAG CCCTGGAGACCCTCGCCCAACTCCACCAGATAGCAGAGGGGTAAG AGAGGATGTGCAAGCGACGACAGATGCTAAAATCCCTGGATCACG ACGCTGCAGAGCACCTTTGCACAGGATGCTGGCCTTTGCTCTTAC TACACTGAGGAGAGATTCCCGCGGGTTCCGCAGGCAGACTACACA GGATGAGGTGGTGGAGTGGAGTGAGAGCAATTGTAACGGTTAACT GTAACGTTTTCTTTCACACACACACACACACACACACACACACAC ATGCTAGGATGCGGAAATCCCCTTATGACTTGCTACTTTTTGATT TTGTGATATTTTGTACTTTTTAGTTGTTCAGCAACTGTCTTATTT AATGGGGAGATTTTAAGTAACATAACTAGTGGCTCTCAGTTAAAA TGTGAGGAAGAACTACAGCTCTTAAATGTAGCAATGGCACTGTTG CAAACTCAGTGCAAACGCCTAGATTGCTTTCTTCTTAACCTATTT ATTTCTTTGTTAAATTTTTCTGATTGTTTCCTTTATAGAGTGTCT CAGGGTGCAGAGGTCAGACTAAGAAATATTCCAAATGTCTTTTAG AAGATAGATGCACTTATGCAGTAAATTATCTTGGGATAGTTCCCA AAAGATTGCTGAAAAAGTAGATTGAGTATAAAAACTTGAAAATAT ATGATGGCTCGTGGGATGTCCTACTATCACTGAACAAACTAAAGG TGCACTGCTTTGGGATTTAATTTCCAGGGTTGCTTGATCATTATA TCATTGGAACAACTGATACTTCACTACTTTAATAAAGAATTAACA GAGATTGAACTCCAAGAGGTGGGTAATTTGGTTTAAAAATACATG TTCATGGGTTTACCACTAACTCCTGAGAAATGTTAAAGGTTCACA GGGGTTCCCTTCTCTCAATGTTTGTAATAATTGCTCATAAGCAAT ACCAGCAATTCATAAAAACTGCTTACTTATGCCATAGAAAATTAA ACACAAAGTGTATACATGTAAAAAAAAAAAAAAAAAA |
| vector name | |
| vector source | |
| enzyme site(DNA insert) | |
| sequencing primer | |
| vector sequence | |
| Gene Location | Chromosome | 9 | |||||||||||
| Location | 9p21 | ||||||||||||
| Strand |
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| Database links | RefSeq | NM_004936 | |||||||||||
| KEGG Genes | 1030 | ||||||||||||
| GeneCard | CDKN2B |
| sequence | sequence of CDS | ATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCAACCGTTTCGGGAGGCGCGCGATCCAGGTCATGATGATGGGCAGCGCCCGCGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCAGACCCTGCCACTCTCACCCGACCGGTGCATGATGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGTCGTCTGCCCGTGGACTTGGCCGAGGAGCGGGGCCACCGCGACGTTGCAGGGTACCTGCGCACAGCCACGGGGGACTGA |
| sequence of protein | MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD | |
| Database link | RefSeq | NM_004936 |
| UniProt | ||
| CCDS |
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Gene Ontology Provided by GOA (www.ebi.ac.uk/GOA)
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| Disease | Summary |
| This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
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